Wastewater-based epidemiology in countries with poor wastewater treatment – Epidemiological indicator function of SARS-CoV-2 RNA in surface waters폐수 처리가 열악한 국가의 폐수 기반 역학 - 지표수에서 SARS-CoV-2 RNA의 역학 지표 기능Article Published on 2022-10-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] adaptation adoption affected alternative analysed applied approach Bacteria Belgrade collected complex complex systems Concentration country COVID-19 Danube effort epidemiological epidemiological purposes Epidemiology Factor Factors Faecal pollution Genes Genetic human populations identify indicated methodology N1 and N2 nucleocapsid outbreak parameter physicochemical primer set primer sets Protein qualitative data quantification quantified Quantitative recipient river RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 surveillance Sava Serbia surface Surface waters Surveillance Treatment Untreated wastewaters. Volume water [DOI] 10.1016/j.scitotenv.2022.156964 PMC 바로가기 [Article Type] Article
Mutation informatics: SARS-CoV-2 receptor-binding domain of the spike proteinArticle Published on 2022-10-012022-11-16 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Amino acid antigenic binding binding interaction change characteristic coronavirus COVID-19 domain entry inhibitors Genetic highlight human Angiotensin-converting enzyme information inhibitor mutated Mutation Mutation informatics physicochemical Protein provide RBD reported resulting SARS-CoV-2 SARS-CoV-2 variants spike spike protein. strain targets the RBD the SARS-CoV-2 the spike protein Variability viral pathogenicity [DOI] 10.1016/j.drudis.2022.06.012 PMC 바로가기
Integrated bioinformatics-cheminformatics approach toward locating pseudo-potential antiviral marine alkaloids against SARS-CoV-2-MproSARS-CoV-2-Mpro에 대한 유사 잠재적 항바이러스 해양 알칼로이드를 찾기 위한 통합 생물정보학-화학정보학 접근Article Published on 2022-09-012022-09-11 Journal: Proteins [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 added Alpha analyzed Antiviral antiviral marine alkaloids approach ATB AutoDock B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta binding energy candidate carried complex Complexes contagious Coronavirus-2 darunavir docking docking study drug drug-likeness drug-likeness profiles prediction Entropy enzyme exhibit free energy H-bond highest Initially investigated Ligand literature review Lopinavir lowest MD simulation MM/PBSA molecular molecular docking molecular docking simulation molecular dynamics Molecular mechanics Molecular Orbital morbidity morbidity and mortality MPro omicron pharmacokinetics pharmacological physicochemical predicted profile profiles protease Protein Protein Data Bank retrieved RMSD RMSF SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2-Mpro. surface area thermodynamic Topology Toxicity variants Virtual screening were assessed were recorded [DOI] 10.1002/prot.26341 PMC 바로가기 [Article Type] Article
Butein as a potential binder of human ACE2 receptor for interfering with SARS-CoV-2 entry: a computer-aided analysisSARS-CoV-2 진입을 방해하기 위한 인간 ACE2 수용체의 잠재적 결합제로서의 부테인: 컴퓨터 지원 분석Article Published on 2022-08-242022-09-11 Journal: Journal of molecular modeling [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin antiviral activity atomic level Butein clinical trials Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated dietary supplement drug candidate effective examined hACE-2. hACE2 hACE2 receptor herbal compound herbal compounds host cell host cells human ACE2 receptor human Angiotensin-converting enzyme In silico methods Infection infections Interaction interfere molecular molecular docking molecular dynamics Molecular modeling natural natural products pathogen Pathogens physicochemical Phytoconstituents profile receptor Recognition researcher SARS-CoV-2 screened selected severe acute respiratory syndrome Coronavirus shown Spike protein subset target protein therapeutic these compound these compounds viral entry viral particle Viral particles zoonotic [DOI] 10.1007/s00894-022-05270-0 PMC 바로가기 [Article Type] Article
Understanding the mutational frequency in SARS-CoV-2 proteome using structural features구조적 특징을 이용한 SARS-CoV-2 프로테옴의 돌연변이 빈도 이해Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Cluster collected computational approach coronavirus COVID-19 develop Early detection feature Features Frequency human population machine machine learning machine learning model machine learning models mutability mutated Mutation mutations pandemic physicochemical predict Protein Protein mutability proteome provided reduced residue SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2. Sequence conservation severe acute respiratory syndrome Coronavirus severity stability Structural analysis survival the SARS-CoV-2 threshold Transmission understanding unique variants variants of concern viral isolate viral isolates Viral protein viral strains virus virus [DOI] 10.1016/j.compbiomed.2022.105708 PMC 바로가기 [Article Type] Article
Synthesis, antimicrobial, molecular docking and molecular dynamics studies of lauroyl thymidine analogs against SARS-CoV-2: POM study and identification of the pharmacophore sitesSARS-CoV-2에 대한 라우로일 티미딘 유사체의 합성, 항균, 분자 도킹 및 분자 역학 연구: POM 연구 및 약전 부위 식별Article Published on 2022-08-012022-09-11 Journal: Bioorganic chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 6LU7 aliphatic Analysis antimicrobial Antimicrobial activities Antiviral aromatic group Bacteria binding binding affinity characterisation chemical structures Combination complex Compound condition COVID-19 COVID-19 pandemic cytotoxicity distribution drug-likeness drug-resistant drugs evaluate experiment FIVE fungi HCQ help Hydroxychloroquine in silico in vitro indicated Interaction investigated less metabolism molecular molecular docking molecular dynamics Molecular dynamics simulation MONITOR nucleoside nucleoside analog nucleoside analogs observation Pass PASS and POM pharmacophore sites identification Pathologies performed Perspective pharmacokinetic physicochemical physiological condition precursor protease respiratory pathologies SARS-CoV-2 SARS-CoV-2 main protease selectivity shown stability Structure Support synthesis synthesised thymidine Thymidine analogs. Treatment viral respiratory was performed [DOI] 10.1016/j.bioorg.2022.105850 PMC 바로가기 [Article Type] Article
Viral immunogenic footprints conferring T cell cross-protection to SARS-CoV-2 and its variantsSARS-CoV-2 및 그 변이체에 T 세포 교차 보호를 부여하는 바이러스 면역원성 발자국Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] 229E 3D structure 3D Structures approach Asymptomatic case Asymptomatic cases CD8+ T cell cellular cellular response concern conserved contributing to Coronaviruses COVID-19 cross-protection cross-reactivity death disease Endemic epitope Epitopes examination expected explain explanation Features Genetic Heterologous HLA-A HLA-A*02:01 human coronaviruses human coronaviruses 229E human infection Immunity immuno informatics immunogenic immunogenic feature immunogenicity include indicate individual individuals infected individuals Infection involved molecular OC43 other coronaviruses outcomes pathogen Pathogens peptide peptides physicochemical Population SARS-CoV SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV-2 sequence sequence Sequence analysis severe disease Structural analysis structural analysis. Structure T cell T-cell T-cell epitopes target Trigger uninfected Vaccine development variant variants virus viruses Wuhan [DOI] 10.3389/fimmu.2022.931372 PMC 바로가기 [Article Type] Article
Essential oil-mediated biocompatible magnesium nanoparticles with enhanced antibacterial, antifungal, and photocatalytic efficacies Research Published on 2022-07-062022-10-05 Journal: Scientific Reports [Category] 치료제, [키워드] acute respiratory syndrome antimicrobial agent Antimicrobials approach attribute coronavirus disease COVID-19 Cymbopogon Degradation Diseases Efficacy Escherichia coli Essential exhibited functional Fusarium highlight imperative investigated microbial infections multifunctional outcome physicochemical reducing reduction Staphylococcus aureus Symptomatic treatment Treatment [DOI] 10.1038/s41598-022-14984-3 [Article Type] Research
The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment에어로졸 미세환경 변화에 따른 SARS-CoV-2 감염 역학Article Published on 2022-07-052022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aerosol aerosol droplet aerosol droplets aerosolization Aerosols Airborne transmission Analysis Bicarbonate buffer caused changes in coronavirus decrease droplet droplets Elevation environmental conditions Factor homogenous initial instrument loss of infectivity measurement microenvironment microphysics microphysics. physical physicochemical probe proportion SARS-CoV-2 severe acute respiratory syndrome Coronavirus stability survival sustained Transmission understanding variants of SARS-CoV-2 virus virus volatilization [DOI] 10.1073/pnas.2200109119 PMC 바로가기 [Article Type] Article
Physicochemical effect of the N501Y, E484K/Q, K417N/T, L452R and T478K mutations on the SARS-CoV-2 spike protein RBD and its influence on agent fitness and on attributes developed by emerging variants of concernSARS-CoV-2 스파이크 단백질 RBD에 대한 N501Y, E484K/Q, K417N/T, L452R 및 T478K 돌연변이의 물리화학적 효과와 에이전트 적합성 및 우려되는 신흥 변이체에 의해 개발된 속성에 대한 영향Review Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, [키워드] addition agent Alter attribute attributes binding caused changes in complex component convalescent sera Effect evade Evolution favor greater immune pressure immunodominant immunogenic induce inducer infection control infection process involved K417N L452R manuscript Mutation mutations N501Y occur Occurrence physicochemical Physicochemical effects Protective antibody RBD Receptor binding domain regions SARS-CoV-2 selective Spike protein spike protein RBD T478K target cells the RBD the SARS-CoV-2 the spike protein therapy Transmissibility turn Vaccine variant Variant of concern. variants of concern Viral transmission virulence virus virus expansion virus genome VoC VOCs [DOI] 10.1016/j.virol.2022.05.003 PMC 바로가기 [Article Type] Review